An Embryotoxic/Teratogenic Potential and Abortifacient Effect Study of Interferon alfacon-1 (Infergen®) via Subcutaneous Administration to Rhesus Monkeys
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چکیده
منابع مشابه
Pharmacokinetics of subcutaneous azidothymidine in rhesus monkeys.
The pharmacokinetics of subcutaneous bolus and continuous infusion azidothymidine (AZT) was studied in rhesus monkeys. Three animals received 100 mg/m2 as a bolus injection both intravenously and subcutaneously, with the order of administration randomly determined. Two animals received a continuous subcutaneous infusion of 25 mg/m2 per h for 12 or 24 h. AZT was measured in plasma by a reverse-p...
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cognitive studies of translation process have recently been awarded a great deal of attention. there exists a psychological angle to almost all translation activities. the present study, thus, deals with analysing the relationships between iranian prospective translators tolerance for ambiguity (ta) and their willingness to translate (wtt). the research was conducted as a mixed methods study, d...
Interferon alfacon-1 protects hamsters from lethal pichinde virus infection.
Hemorrhagic fever of arenaviral origin is a frequently fatal infectious disease of considerable priority to the biodefense mission. Historically, the treatment of arenaviral infections with alpha interferons has not yielded favorable results. Here we present evidence that interferon alfacon-1, a nonnaturally occurring bioengineered alpha interferon approved for the treatment of chronic hepatiti...
متن کاملInterferon alfacon-1 plus corticosteroids in severe acute respiratory syndrome: a preliminary study.
CONTEXT Severe acute respiratory syndrome (SARS) is a new clinical entity for which no effective therapeutic strategy has been developed. OBJECTIVE To provide preliminary results on the potential therapeutic benefit and tolerability of interferon alfacon-1 plus corticosteroids for SARS. DESIGN, SETTING, AND PATIENTS Open-label study of 22 patients diagnosed as having probable SARS at North ...
متن کاملSingle subcutaneous dosing of cefovecin in rhesus monkeys (Macaca mulatta): a pharmacokinetic study.
Cefovecin is a third-generation cephalosporin approved for antibacterial treatment with a 14-day dosing interval in dogs and cats. This antibiotic may also be useful for zoo and wildlife veterinary medicine, because of its broad spectrum and long duration of activity. The aim of the study was to determine whether cefovecin is a suitable antibiotic to prevent skin wound infection in rhesus monke...
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ژورنال
عنوان ژورنال: Congenital Anomalies
سال: 1999
ISSN: 0914-3505,1741-4520
DOI: 10.1111/j.1741-4520.1999.tb00562.x